The United States announced Thursday that it is to withdraw from the United Nations Scientific and Cultural Organization, accusing the body of “anti-Israel bias.”

State Department spokeswoman Heather Nauert said Washington would establish an “observer mission” to replace its representation at the Paris-based agency.

US withdrawal deals a further blow to an organization hobbled by regional rivalries and a lack of funds.

UNESCO said the withdrawal was a loss to the “UN family” and to multilateralism.

The agency is known for designating world heritage sites such as Syria’s Palmyra and the US Grand Canyon.

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